CBD and CP450

Cytochrome P450 family comprise 18 families and about 50 isoenzymes. Inflammation inhibits the induction of some P450 isoforms (and drug metabolization). THC and its metabolites are reversible inhibitors of several isoforms of P450. "The inhibition of CYP2B6 by CBD is attributed to the influence of free hydroxyl phenol groups and the pentyl side chain" [1].

[1]

C. D. F. Fonseca, O. Zendulka, and J. Juřica, “Cannabinoids and the endocannabinoid system in the regulation of cytochrome p450 metabolic activity-a review,” Front. pharmacol., vol. 16, Jun. 2025, doi: 10.3389/fphar.2025.1599012. Available: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1599012/full. [Accessed: Nov. 04, 2025]