mTOR in acquired epilepsy

mTOR signaling is enhanced in diverse epilepsy models. Phosporylated S6 is a marker of mTOR pathway activation (through immunostaining). Rapamycin prevents hippocampal granule cell mossy fiber sprouting, dendritic change, regulate ion channel expression, and block increases in spotaneous excitatory current frequency [1] A limitations of rapamycin as a treatment in epilepsy is that also it inhibits interneuron sprouting (parvalbumin and somatostatin-expressing interneurons [1]. So mTOR might cause anti and pro-epileptogenic effects.