A Biophysical Model of Endocannabinoid-Mediated Short Term Depression in Hippocampal Inhibition

===============================================================================================

Introducción

============
  • Cannabinoid signalling is an important modulator of plasticity for both inhibitory and excitatory plasticity
  • eCB have a unconventional retrograde signalling system important for many physiological processes
  • eCBs produce eCB-iSTD (produced by reduction in the release of GABA from interneurons) and eCB-eSTD (produced by reduction in the release of GLU from excitatory neurons).
  • eCB synthesis is stimulated by increases in intracellular Ca2+.
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------