Metabolic Dysfunction and Oxidative Stress in Epilepsy
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Source: Metabolic Dysfunction and Oxidative Stress in Epilepsy
Introduction
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- currently available therapeutics target ion channels or neurotransmitter systems
Sources of Reactive Species and Oxidative Stress
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- free radical: any chemical species with one or more unpaired electrons in their external orbit
- ROS/RNS:
- oxygen, superoxide (O2\(^-\)), H2O2, Nitric oxide (NO), hydroxyl radical (HO) and peroxynitrite (ONOO\(^-\))